Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters
Data(s) |
01/01/2004
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Resumo |
Cone snails have evolved a vast array of peptide toxins for prey capture and defence. These peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in normal and diseased states. A number of these peptides have shown efficacy in vivo, including inhibitors of calcium channels, the norepinephrine transporter, nicotinic acetylcholine receptors, NMDA receptors and neurotensin receptors, with several having undergone pre-clinical or clinical development for the treatment of pain. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Taylor & Francis |
Palavras-Chave | #Biochemistry & Molecular Biology #Cell Biology #Calcium Channel #Sodium Channel #Norepinephrine Transporter #Nicotinic Acetylcholine Receptor #Nmda Receptor #Neurotensin Receptor #Omega-conotoxins #Conantokin-g #Subtypes #Venom #Antinociception #Conopeptides #Peptides #Release #Rats #C1 #320305 Medical Biochemistry - Proteins and Peptides #730104 Nervous system and disorders |
Tipo |
Journal Article |