The ins and outs of E-cadherin trafficking
Data(s) |
01/08/2004
|
---|---|
Resumo |
One way of controlling the activity of E-cadherin - a protein that is, simultaneously, a major cell-adhesion molecule, a powerful tumour suppressor, a determinant of cell polarity and a partner to the potent catenin signalling molecules - is to keep it on the move. During the past two decades, many insights into the fundamental role of E-cadherin in these processes have been garnered. Studies during the past five years have begun to reveal the importance of intracellular trafficking as a means of regulating the functions of E-cadherin. E-cadherin is trafficked to and from the cell surface by exocytic and multiple endocytic pathways. In this article, we survey the vesicle-trafficking machinery that is responsible for the sorting, transport, actin association and vesicle targeting of E-cadherin to regulate its movement and function during growth and development and, possibly, in cancer. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier Trends Journals |
Palavras-Chave | #Cell Biology #Cell-cell Adhesion #Epithelial-mesenchymal Transitions #Nucleotide Exchange Factor #Apical-junctional Complex #Basal-lateral Membrane #Regulates E-cadherin #Trans-golgi Network #Darby Canine Kidney #Protein-kinase-c #Adherens Junctions #C1 #270103 Protein Targeting and Signal Transduction #780106 Political science and public policy |
Tipo |
Journal Article |