Functional memory CD8+ T cells can be generated in vivo without evident T help
Contribuinte(s) |
James B. Campbell K. Yamanishi D. R. E. Spier |
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Data(s) |
21/12/2004
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Resumo |
Synthetic cytotoxic T cell (CTL) epitope peptides provide an effective and safe means of vaccination against cancers and viruses, as these peptides can induce specific CD8+ effector T cells in vivo. However, the effector CD8+ T cells induced by the minimal CTL epitope peptides do not last past about 3 weeks after the induction and no functional memory CD8+ T cells are generated. It is held that simultaneous induction of CD4+ T cells by incorporating peptides containing T-helper epitopes in the vaccine at the time of primary vaccination are necessary for the induction of long-lived functional memory CD8+ T cells. We now report that, surprisingly, incorporation of medium length (>20 AA) peptides devoid of detectable T-helper epitopes in a minimal CTL epitope-based vaccine can also induce long-lasting! functional rumour antigen specific memory CD8+ T cells that are capable of promoting protection against tumour challenge. This observation may have implications for the formulation of therapeutic anti-cancer and anti-virus peptide vaccines where a strong induction of CD4 T help would be undesirable. (C) 2004 Elsevier Ltd. All rights reserved. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier Ltd. |
Palavras-Chave | #Immunology #Medicine, Research & Experimental #Veterinary Sciences #Memory T Cells #Peptide Vaccines #Danger Signal #Tlr #Human-papillomavirus Type-16 #Transforming Protein #Cd8-t-cell Memory #Cd4-t-cell Help #Epitope #Tumors #C1 #320202 Cellular Immunology #730101 Infectious diseases |
Tipo |
Journal Article |