Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections


Autoria(s): Yang, I. A.; Seeney, S. L.; Wolter, J. M.; Anders, E. M.; McCormack, J. G.; Tunnicliffe, A. M.; Rabnott, G. C.; Shaw, J. G.; Dent, A. G.; Kim, S. T.; Zimmerman, P. V.; Fong, K. M.
Contribuinte(s)

G. Gallagher

M. F. Seldin

Data(s)

01/06/2003

Resumo

Infection frequently causes exacerbations of chronic obstructive pulmonary disease (COPD). Mannose-binding lectin (MBL) is a pattern-recognition receptor that assists in clearing microorganisms. Polymorphisms in the MBL2 gene reduce serum MBL levels and are associated with risk of infection. We studied whether the MBL2 codon 54 B allele affected serum MBL levels, admissions for infective exacerbation in COPD and disease susceptibility. Polymorphism frequency was determined by PCR-RFLP in 200 COPD patients and 104 smokers with normal lung function. Serum MBL was measured as mannan-binding activity in a subgroup of 82 stable COPD patients. Frequency of COPD admissions for infective exacerbation was ascertained for a 2-year period. The MBL2 codon 54 B allele reduced serum MBL in COPD patients. In keeping, patients carrying the low MBL-producing B allele had increased risk of admission for infective exacerbation (OR 4.9, P-corrected = 0.011). No association of MBL2 genotype with susceptibility to COPD was detected. In COPD, serum MBL is regulated by polymorphism at codon 54 in its encoding gene. Low MBL-producing genotypes were associated with more frequent admissions to hospital with respiratory infection, suggesting that the MBL2 gene is disease-modifying in COPD. MBL2 genotype should be explored prospectively as a prognostic marker for infection risk in COPD.

Identificador

http://espace.library.uq.edu.au/view/UQ:66396

Idioma(s)

eng

Publicador

Nature Publishing Group

Palavras-Chave #Genetics & Heredity #Immunology #Pulmonary Disease #Chronic Obstructive #Polymorphism (genetics) #Mannose-binding Lectin #Obstructive Pulmonary-disease #Cystic-fibrosis #Lung-function #Airway Infection #Mbl Genotype #Association #Decline #Protein #Susceptibility #Deficiency #C1 #321027 Respiratory Diseases #730110 Respiratory system and diseases (incl. asthma) #321010 Infectious Diseases #730101 Infectious diseases
Tipo

Journal Article