The CD1d natural killer T-cell antigen presentation pathway is highly conserved between humans and rhesus macaques
Contribuinte(s) |
R. E. Bontrop |
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Data(s) |
01/01/2003
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Resumo |
Natural killer T (NKT) cells play an important role in controlling cancers, infectious diseases and autoimmune diseases. Although the rhesus macaque is a useful primate model for many human diseases such as infectious and autoimmune diseases, little is known about their NKT cells. We analyzed Valpha24TCR+ T cells from rhesus macaque peripheral blood mononuclear cells stimulated with aalpha-galactosylceramide (a-GalCer) and interleukin-2. We found that rhesus macaques possess Va24TCR+ T cells, suggesting that recognition of alpha-GalCer is highly conserved between rhesus macaques and humans. The amino acid sequences of the V-J junction for the Valpha24TCR of rhesus macaque and human NKT cells are highly conserved (93% similarity), and the CD1d alpha1-alpha2 domains of both species are highly homologous (95.6%). These findings indicate that the rhesus macaque is a useful primate model for understanding the contribution of NKT cells to the control of human diseases. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Springer-Verlag |
Palavras-Chave | #Genetics & Heredity #Immunology #Alpha-galcer #Cd1d #V Alpha 24nkt #Rhesus Macaque #Nonhuman Primate #Alpha-galactosylceramide #Nkt Cells #Selective Reduction #Presenting Function #Dendritic Cells #Recognition #Thymocytes #Receptor #Krn7000 #Mice #C1 #320207 Autoimmunity #730108 Cancer and related disorders |
Tipo |
Journal Article |