Successful prevention of transmission of integrase resistance in the Swiss HIV Cohort Study.
| Data(s) |
29/04/2016
31/12/1969
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|---|---|
| Resumo |
Prevalence of integrase inhibitor (INSTI) transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analysed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1,316 (0.1%) drug-naïve samples a major INSTI TDR mutation was detected. Prevalence was stable although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes where more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR affecting a new drug class for years. |
| Formato |
application/pdf application/pdf |
| Identificador |
http://boris.unibe.ch/82117/1/infdis.jiw165.full.pdf http://boris.unibe.ch/82117/8/infdis.jiw165.full.pdf Scherrer, Alexandra U; Yang, Wan-Lin; Kouyos, Roger D; Böni, Jürg; Yerly, Sabine; Klimkait, Thomas; Aubert, Vincent; Cavassini, Matthias; Battegay, Manuel; Hauser, Christoph; Calmy, Alexandra; Schmid, Patrick; Bernasconi, Enos; Günthard, Huldrych F (2016). Successful prevention of transmission of integrase resistance in the Swiss HIV Cohort Study. Journal of infectious diseases, 214(3), pp. 399-402. Oxford University Press 10.1093/infdis/jiw165 <http://dx.doi.org/10.1093/infdis/jiw165> doi:10.7892/boris.82117 info:doi:10.1093/infdis/jiw165 info:pmid:27130429 urn:issn:0022-1899 |
| Idioma(s) |
eng |
| Publicador |
Oxford University Press |
| Relação |
http://boris.unibe.ch/82117/ |
| Direitos |
info:eu-repo/semantics/embargoedAccess info:eu-repo/semantics/restrictedAccess |
| Fonte |
Scherrer, Alexandra U; Yang, Wan-Lin; Kouyos, Roger D; Böni, Jürg; Yerly, Sabine; Klimkait, Thomas; Aubert, Vincent; Cavassini, Matthias; Battegay, Manuel; Hauser, Christoph; Calmy, Alexandra; Schmid, Patrick; Bernasconi, Enos; Günthard, Huldrych F (2016). Successful prevention of transmission of integrase resistance in the Swiss HIV Cohort Study. Journal of infectious diseases, 214(3), pp. 399-402. Oxford University Press 10.1093/infdis/jiw165 <http://dx.doi.org/10.1093/infdis/jiw165> |
| Palavras-Chave | #610 Medicine & health |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
