A3.6 Two components contributing to reduced treg surface CD25 in sle patients and their unaffected relatives

Autoria(s): Costa, N; Marques, O; Godinho, S; Carvalho, C; Leal, B; Vasconcelos, C; Marinho, A; Moraes-Fontes, M F; Gomes da Costa, A; Ponte, C; Marques, R; Coias, T; Martins, A R; Viana, J F; Martins, B; Fesel, C
Data(s)

08/07/2016

08/07/2016

01/03/2014
Resumo

Background FOXP3+ regulatory T-cells (Tregs) in Systemic Lupus Erythematosus (SLE) are in a functionally deficient state with a characteristic reduction or absence of surface CD25 (the IL-2 receptor alpha chain). Genetic variation in the CD25-encoding IL2RA locus is associated with other autoimmune disorders.
Identificador

A3.6 Two components contributing to reduced treg surface CD25 in sle patients and their unaffected relatives N Costa, O Marques, S Godinho, C Carvalho, B Leal, C Vasconcelos, A Marinho, M F Moraes-Fontes, A Gomes da Costa, C Ponte, R Marques, T Coias, A R Martins, J F Viana, B Martins, C Fesel Ann Rheum Dis 2014;73:Suppl 1 A44 doi:10.1136/annrheumdis-2013-205124.100

http://hdl.handle.net/10400.7/677

10.1136/annrheumdis-2013-205124.100
Idioma(s)

eng
Publicador

BMJ Publishing Group
Relação

http://ard.bmj.com/content/73/Suppl_1/A44.1
Direitos

openAccess
Palavras-Chave #Systemic Lupus Erythematosus (SLE) #CD25 #FOXP3+
Tipo

article
Acesso ao item digital