Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells
| Data(s) |
05/07/2016
05/07/2016
14/10/2012
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| Resumo |
Intravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of circulating T-cells and reduced activity of CD4 + Foxp3+ regulatory T-cells (Tregs) reflected by lower CD25 surface density. Octapharma research funding; Fundação para a Ciência e a Tecnologia postdoctoral fellowships: (SFRH/BPD/20806/2004, SFRH/BPD/34648/2007); FCT Programa Pessoa travel grant. |
| Identificador |
Costa, N et al. J Clin Immunol (2013) 33: 349. doi:10.1007/s10875-012-9816-7 http://hdl.handle.net/10400.7/676 10.1007/s10875-012-9816-7 |
| Idioma(s) |
eng |
| Publicador |
Springer Verlag |
| Relação |
http://link.springer.com/article/10.1007%2Fs10875-012-9816-7 |
| Direitos |
openAccess |
| Palavras-Chave | #Adult #Forkhead Transcription Factors #Humans #Interleukin-2 Receptor alpha Subunit #Longitudinal Studies #Lupus Erythematosus, Systemic #Middle Aged #Receptors, Antigen, T-Cell, alpha-beta #T-Lymphocyte Subsets #T-Lymphocytes, Regulatory #Young Adult #Immunoglobulins, Intravenous |
| Tipo |
article |
