Organocatalytic Asymmetric α-Chlorination of 1,3-Dicarbonyl Compounds Catalyzed by 2-Aminobenzimidazole Derivatives
| Contribuinte(s) |
Universidad de Alicante. Departamento de Química Orgánica Universidad de Alicante. Instituto Universitario de Síntesis Orgánica Catálisis Estereoselectiva en Síntesis Orgánica (CESO) Nuevos Materiales y Catalizadores (MATCAT) |
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| Data(s) |
19/01/2016
19/01/2016
13/01/2016
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| Resumo |
Bifunctional chiral 2-aminobenzimidazole derivatives 1 and 2 catalyze the enantioselective stereodivergent α-chlorination of β-ketoesters and 1,3-diketone derivatives with up to 50% ee using N-chlorosuccinimide (NCS) or 2,3,4,4,5,6-hexachloro-2,5-cyclohexadien-1-one as electrophilic chlorine sources. Financial support from the University of Alicante (VIGROB-173, VIGROB-285, GRE12-03, UAUSTI13-01, UAUSTI13-02), and Spanish Ministerio de Economía y Competitividad (CTQ2011-24151) is acknowledged. |
| Identificador |
Sánchez DS, Baeza A, Alonso DA. Organocatalytic Asymmetric α-Chlorination of 1,3-Dicarbonyl Compounds Catalyzed by 2-Aminobenzimidazole Derivatives. Symmetry. 2016; 8(1):3. doi:10.3390/sym8010003 2073-8994 http://hdl.handle.net/10045/52479 10.3390/sym8010003 |
| Idioma(s) |
eng |
| Publicador |
MDPI |
| Relação |
http://dx.doi.org/10.3390/sym8010003 |
| Direitos |
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). info:eu-repo/semantics/openAccess |
| Palavras-Chave | #Organocatalysis #Electrophilic chlorination #Asymmetric catalysis #Dicarbonyl compounds #Benzimidazole #Química Orgánica |
| Tipo |
info:eu-repo/semantics/article |
