Herpesviruses use bidirectional fast-axonal transport to spread in sensory neurons


Autoria(s): Smith, Gregory A.; Gross, Steven P.; Enquist, Lynn W.
Data(s)

13/03/2001

Resumo

Alpha herpesviruses infect the vertebrate nervous system resulting in either mild recurrent lesions in mucosal epithelia or fatal encephalitis. Movement of virions within the nervous system is a critical factor in the outcome of infection; however, the dynamics of individual virion transport have never been assessed. Here we visualized and tracked individual viral capsids as they moved in axons away from infected neuronal cell bodies in culture. The observed movement was compatible with fast axonal flow mediated by multiple microtubule motors. Capsids accumulated at axon terminals, suggesting that spread from infected neurons required cell contact.

Identificador

/pmc/articles/PMC30676/

/pubmed/11248101

http://dx.doi.org/10.1073/pnas.061029798

Idioma(s)

en

Publicador

The National Academy of Sciences

Direitos

Copyright © 2001, The National Academy of Sciences

Palavras-Chave #Biological Sciences
Tipo

Text