Impaired survival of T helper cells in the absence of CD4


Autoria(s): Strong, Julie; Wang, Qi; Killeen, Nigel
Data(s)

27/02/2001

20/02/2001

Resumo

Signal transduction in response to ligand recognition by T cell receptors regulates T cell fate within and beyond the thymus. Herein we examine the involvement of the CD4 molecule in the regulation of T helper cell survival. T helper cells that lack CD4 expression are prone to apoptosis and show diminished survival after adoptive transfer to irradiated recipients. The helper lineage in CD4−/− animals shows a higher than normal apparent rate of cell division and is also enriched for cells exhibiting a memory cell phenotype. Thus the data point to a necessary role for CD4 in the regulation of T helper cell survival and homeostasis.

Identificador

/pmc/articles/PMC30178/

/pubmed/11226279

http://dx.doi.org/10.1073/pnas.051329698

Idioma(s)

en

Publicador

The National Academy of Sciences

Direitos

Copyright © 2001, The National Academy of Sciences

Palavras-Chave #Biological Sciences
Tipo

Text