Changes in the Papez Circuit in early stages of Alzheimer's Disease


Autoria(s): García-Polo, Pablo; Pajares, Gonzalo; Hernández Tamames, J.A.; Alfayate, E.; Frank, A.; Alvarez Linera, Juan
Data(s)

2011

Resumo

Alzheimer's disease (AD) is the most common cause of demenMa. Neuronal and synapMc losses occur iniMally and predominantly in the medial temporal lobe structures including hippocampus, amygdala and thalamus, structures that belong to the Papez circuit. The integrity of the connecMons amongst them is essenMal for episodic memory, which is specifically impaired in AD. For this reason we have invesMgated the degeneraMon paRern of subcorMcal structures and its relaMon to early stages of AD, i.e. Mild CogniMve Impairment (MCI), both in the amnesic and mulMdomain types using structural magneMc resonance imaging (using a 3T GE scanner) and VBM‐DARTEL.

Formato

application/pdf

Identificador

http://oa.upm.es/13589/

Idioma(s)

spa

Relação

http://oa.upm.es/13589/1/INVE_MEM_2011_115104.pdf

Direitos

http://creativecommons.org/licenses/by-nc-nd/3.0/es/

info:eu-repo/semantics/openAccess

Fonte

Global Alzheimer's Research Summit | Global Alzheimer's Research Summit | 2011 | Madrid

Palavras-Chave #Medicina
Tipo

info:eu-repo/semantics/conferenceObject

Ponencia en Congreso o Jornada

PeerReviewed