Manually calculated oesophageal bolus clearance time increases in parallel with reflux severity at impedance-pH monitoring.
Data(s) |
01/12/2015
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Resumo |
BACKGROUND Oesophageal clearance has been scarcely studied. AIMS Oesophageal clearance in endoscopy-negative heartburn was assessed to detect differences in bolus clearance time among patients sub-grouped according to impedance-pH findings. METHODS In 118 consecutive endoscopy-negative heartburn patients impedance-pH monitoring was performed off-therapy. Acid exposure time, number of refluxes, baseline impedance, post-reflux swallow-induced peristaltic wave index and both automated and manual bolus clearance time were calculated. Patients were sub-grouped into pH/impedance positive (abnormal acid exposure and/or number of refluxes) and pH/impedance negative (normal acid exposure and number of refluxes), the former further subdivided on the basis of abnormal/normal acid exposure time (pH+/-) and abnormal/normal number of refluxes (impedance+/-). RESULTS Poor correlation (r=0.35) between automated and manual bolus clearance time was found. Manual bolus clearance time progressively decreased from pH+/impedance+ (42.6s), pH+/impedance- (27.1s), pH-/impedance+ (17.8s) to pH-/impedance- (10.8s). There was an inverse correlation between manual bolus clearance time and both baseline impedance and post-reflux swallow-induced peristaltic wave index, and a direct correlation between manual bolus clearance and acid exposure time. A manual bolus clearance time value of 14.8s had an accuracy of 93% to differentiate pH/impedance positive from pH/impedance negative patients. CONCLUSIONS When manually measured, bolus clearance time reflects reflux severity, confirming the pathophysiological relevance of oesophageal clearance in reflux disease. |
Formato |
application/pdf |
Identificador |
de Bortoli, Nicola; Martinucci, Irene; Savarino, Edoardo V; Frazzoni, Marzio; Tutuian, Radu; Tolone, Salvatore; Piaggi, Paolo; Furnari, Manuele; Russo, Salvatore; Bertani, Lorenzo; Macchia, Lorenzo; Savarino, Vincenzo; Marchi, Santino (2015). Manually calculated oesophageal bolus clearance time increases in parallel with reflux severity at impedance-pH monitoring. Digestive and liver disease, 47(12), pp. 1027-1032. Elsevier 10.1016/j.dld.2015.08.010 <http://dx.doi.org/10.1016/j.dld.2015.08.010> doi:10.7892/boris.80372 info:doi:10.1016/j.dld.2015.08.010 info:pmid:26362613 urn:issn:1590-8658 |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://boris.unibe.ch/80372/ |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
de Bortoli, Nicola; Martinucci, Irene; Savarino, Edoardo V; Frazzoni, Marzio; Tutuian, Radu; Tolone, Salvatore; Piaggi, Paolo; Furnari, Manuele; Russo, Salvatore; Bertani, Lorenzo; Macchia, Lorenzo; Savarino, Vincenzo; Marchi, Santino (2015). Manually calculated oesophageal bolus clearance time increases in parallel with reflux severity at impedance-pH monitoring. Digestive and liver disease, 47(12), pp. 1027-1032. Elsevier 10.1016/j.dld.2015.08.010 <http://dx.doi.org/10.1016/j.dld.2015.08.010> |
Palavras-Chave | #610 Medicine & health |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |