ER strikes again: Proteostasis Dysfunction In ALS
| Data(s) |
11/03/2016
|
|---|---|
| Resumo |
The precise contribution of endoplasmic reticulum (ER) chaperone protein disulfide isomerase (PDI) variants in human amyotrophic lateral sclerosis (ALS) patients to the pathogenesis of ALS remained unclear. In the present study, Woehlbier et al (2016) demonstrated that these PDI variants are capable of altering motor neuron morphology, impairing the expression of synaptic proteins, and compromising neuromuscular junction (NMJ) integrity. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/79961/1/EMBO%20J.pdf Maharjan, Niran; Saxena, Smita (2016). ER strikes again: Proteostasis Dysfunction In ALS. EMBO journal, 35(8), pp. 798-800. Nature Publishing Group 10.15252/embj.201694117 <http://dx.doi.org/10.15252/embj.201694117> doi:10.7892/boris.79961 info:doi:10.15252/embj.201694117 info:pmid:26968985 urn:issn:0261-4189 |
| Idioma(s) |
eng |
| Publicador |
Nature Publishing Group |
| Relação |
http://boris.unibe.ch/79961/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Maharjan, Niran; Saxena, Smita (2016). ER strikes again: Proteostasis Dysfunction In ALS. EMBO journal, 35(8), pp. 798-800. Nature Publishing Group 10.15252/embj.201694117 <http://dx.doi.org/10.15252/embj.201694117> |
| Palavras-Chave | #570 Life sciences; biology #610 Medicine & health |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
