Transcriptional regulation of tenascin genes


Autoria(s): Chiovaro, Francesca; Chiquet-Ehrismann, Ruth; Chiquet, Matthias
Data(s)

2015

Resumo

Extracellular matrix proteins of the tenascin family resemble each other in their domain structure, and also share functions in modulating cell adhesion and cellular responses to growth factors. Despite these common features, the 4 vertebrate tenascins exhibit vastly different expression patterns. Tenascin-R is specific to the central nervous system. Tenascin-C is an "oncofetal" protein controlled by many stimuli (growth factors, cytokines, mechanical stress), but with restricted occurrence in space and time. In contrast, tenascin-X is a constituitive component of connective tissues, and its level is barely affected by external factors. Finally, the expression of tenascin-W is similar to that of tenascin-C but even more limited. In accordance with their highly regulated expression, the promoters of the tenascin-C and -W genes contain TATA boxes, whereas those of the other 2 tenascins do not. This article summarizes what is currently known about the complex transcriptional regulation of the 4 tenascin genes in development and disease.

Formato

application/pdf

Identificador

http://boris.unibe.ch/76771/1/Transcriptional%20regulation%20of%20tenascin.pdf

Chiovaro, Francesca; Chiquet-Ehrismann, Ruth; Chiquet, Matthias (2015). Transcriptional regulation of tenascin genes. Cell adhesion & migration, 9(1-2), pp. 34-47. Landes Bioscience 10.1080/19336918.2015.1008333 <http://dx.doi.org/10.1080/19336918.2015.1008333>

doi:10.7892/boris.76771

info:doi:10.1080/19336918.2015.1008333

info:pmid:25793574

urn:issn:1933-6918

Idioma(s)

eng

Publicador

Landes Bioscience

Relação

http://boris.unibe.ch/76771/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Chiovaro, Francesca; Chiquet-Ehrismann, Ruth; Chiquet, Matthias (2015). Transcriptional regulation of tenascin genes. Cell adhesion & migration, 9(1-2), pp. 34-47. Landes Bioscience 10.1080/19336918.2015.1008333 <http://dx.doi.org/10.1080/19336918.2015.1008333>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed