p73 regulates basal and starvation-induced liver metabolism in vivo


Autoria(s): He, Zhaoyue; Agostini, Massimiliano; Liu, He; Melino, Gerry; Simon, Hans-Uwe
Data(s)

07/09/2015

Resumo

As a member of the p53 gene family, p73 regulates cell cycle arrest, apoptosis, neurogenesis, immunity and inflammation. Recently, p73 has been shown to transcriptionally regulate selective metabolic enzymes, such as cytochrome c oxidase subunit IV isoform 1, glucose 6-phosphate dehydrogenase and glutaminase-2, resulting in significant effects on metabolism, including hepatocellular lipid metabolism, glutathione homeostasis and the pentose phosphate pathway. In order to further investigate the metabolic effect of p73, here, we compared the global metabolic profile of livers from p73 knockout and wild-type mice under both control and starvation conditions. Our results show that the depletion of all p73 isoforms cause altered lysine metabolism and glycolysis, distinct patterns for glutathione synthesis and Krebs cycle, as well as an elevated pentose phosphate pathway and abnormal lipid accumulation. These results indicate that p73 regulates basal and starvation-induced fuel metabolism in the liver, a finding that is likely to be highly relevant for metabolism-associated disorders, such as diabetes and cancer.

Formato

application/pdf

Identificador

http://boris.unibe.ch/75856/1/p73%20regulates%20basal%20and%20starvation-induced%20liver%20metabolism%20in%20vivo.pdf

He, Zhaoyue; Agostini, Massimiliano; Liu, He; Melino, Gerry; Simon, Hans-Uwe (2015). p73 regulates basal and starvation-induced liver metabolism in vivo. OncoTarget, 6(32), pp. 33178-33190. Impact Journals LLC 10.18632/oncotarget.5090 <http://dx.doi.org/10.18632/oncotarget.5090>

doi:10.7892/boris.75856

info:doi:10.18632/oncotarget.5090

info:pmid:26375672

urn:issn:1949-2553

Idioma(s)

eng

Publicador

Impact Journals LLC

Relação

http://boris.unibe.ch/75856/

Direitos

info:eu-repo/semantics/openAccess

Fonte

He, Zhaoyue; Agostini, Massimiliano; Liu, He; Melino, Gerry; Simon, Hans-Uwe (2015). p73 regulates basal and starvation-induced liver metabolism in vivo. OncoTarget, 6(32), pp. 33178-33190. Impact Journals LLC 10.18632/oncotarget.5090 <http://dx.doi.org/10.18632/oncotarget.5090>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

NonPeerReviewed