The role of anti-VEGF agents in myopic choroidal neovascularization: Current standards and future outlook


Autoria(s): Munk, Marion; Rückert, Rene; Zinkernagel, Martin; Ebneter, Andreas; Wolf, Sebastian
Data(s)

2016

Resumo

Introduction The global prevalence of pathologic myopia is 0.9-3.1%, and visual impairment is found in 0.1-0.5% of European and 0.2-1.4% of Asian studies. Myopic choroidal neovascularization (mCNV) affects 5.2-11.3% of pathologic myopia patients and is a leading cause of vision impairment in the working-age population. Characteristic morphological changes and visual-acuity decrease are diagnostic features. Vascular-Endothelial-Growth-Factor (VEGF) has been identified as a trigger for pathologic neovascularization in these highly myopic patients. Areas Covered We cover the epidemiology, pathology and diagnostic aspects of mCNV. The history of therapeutic interventions is described, followed by an overview of current standard-of-care (SOC)-blocking VEGF using bevacizumab (off-label), ranibizumab or aflibercept and improving vision up to 13.5-14.4 letters. Despite good efficacy, an unmet medical need remains. We summarize ongoing and future developments of new drugs to treat or potentially cure mCNV. Expert Opinion mCNV is a major global health concern. Early detection and treatment is key for a satisfying outcome. The current SOC, VEGF inhibitors, affords good therapeutic efficacy and reasonable disease stabilization with few intravitreal treatments per year. However, the long-term prognosis is still unsatisfactory, and side-effects like chorioretinal atrophy development are of concern. Therefore, efforts should be intensified to develop more effective therapies.

Formato

application/pdf

Identificador

http://boris.unibe.ch/74442/1/The%20role%20of%20anti%20VEGF%20agents%20in%20myopic%20choroidal%20neovascularization%20Current%20standards%20and%20future%20outlook.pdf

Munk, Marion; Rückert, Rene; Zinkernagel, Martin; Ebneter, Andreas; Wolf, Sebastian (2016). The role of anti-VEGF agents in myopic choroidal neovascularization: Current standards and future outlook. Expert Opinion on Biological Therapy, 16(4), pp. 477-487. Informa Healthcare 10.1517/14712598.2016.1132696 <http://dx.doi.org/10.1517/14712598.2016.1132696>

doi:10.7892/boris.74442

info:doi:10.1517/14712598.2016.1132696

info:pmid:26666589

urn:issn:1471-2598

Idioma(s)

eng

Publicador

Informa Healthcare

Relação

http://boris.unibe.ch/74442/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Munk, Marion; Rückert, Rene; Zinkernagel, Martin; Ebneter, Andreas; Wolf, Sebastian (2016). The role of anti-VEGF agents in myopic choroidal neovascularization: Current standards and future outlook. Expert Opinion on Biological Therapy, 16(4), pp. 477-487. Informa Healthcare 10.1517/14712598.2016.1132696 <http://dx.doi.org/10.1517/14712598.2016.1132696>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed