In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa.
| Data(s) |
01/12/2015
|
|---|---|
| Resumo |
The in vitro activity of the novel antimicrobial peptide dendrimer G3KL was evaluated against 32 Acinetobacter baumannii (including 10 OXA-23, 7 OXA-24, and 11 OXA-58 carbapenemase producers) and 35 Pseudomonas aeruginosa (including 18 VIM and 3 IMP carbapenemase producers) strains and compared to the activities of standard antibiotics. Overall, both species collections showed MIC50/90 values of 8/8 μg/ml and minimum bactericidal concentrations at which 50% or 90% of strains tested are killed (MBC50/90) of 8/8 μg/ml. G3KL is a promising molecule with antibacterial activity against multidrug-resistant and extensively drug-resistant A. baumannii and P. aeruginosa isolates. |
| Formato |
text/html |
| Identificador |
http://boris.unibe.ch/74425/1/7915.full.pdf%2Bhtml Pires, João; Siriwardena, Thissa N.; Stach, Michaela; Tinguely, Regula; Kasraian Fard, Sara; Luzzaro, Francesco; Leib, Stephen; Darbre, Tamis; Reymond, Jean-Louis; Endimiani, Andrea (2015). In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 59(12), pp. 7915-7918. American Society for Microbiology 10.1128/AAC.01853-15 <http://dx.doi.org/10.1128/AAC.01853-15> doi:10.7892/boris.74425 info:doi:10.1128/AAC.01853-15 info:pmid:26459893 urn:issn:0066-4804 |
| Idioma(s) |
eng |
| Publicador |
American Society for Microbiology |
| Relação |
http://boris.unibe.ch/74425/ http://aac.asm.org/content/59/12/7915.long |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Pires, João; Siriwardena, Thissa N.; Stach, Michaela; Tinguely, Regula; Kasraian Fard, Sara; Luzzaro, Francesco; Leib, Stephen; Darbre, Tamis; Reymond, Jean-Louis; Endimiani, Andrea (2015). In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 59(12), pp. 7915-7918. American Society for Microbiology 10.1128/AAC.01853-15 <http://dx.doi.org/10.1128/AAC.01853-15> |
| Palavras-Chave | #570 Life sciences; biology #610 Medicine & health #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
