Thiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugs
| Data(s) |
2016
|
|---|---|
| Resumo |
Water-soluble arene ruthenium complexes have been intensively studied as cytotoxic compounds for the last fifteen years, notably owing to the promising in vitro and in vivo evaluations of, respectively, RAPTA-C (η6-p-MeC6H4Pri)Ru(P-pta)Cl2 (pta = 1,3,5-triaza-7-phospha-tricyclo-[3.3.1.1]decane) from Dyson's laboratory, and the (η6-arene)Ru(en)Cl]+ (en = ethylenediamine, RAED) family of compounds from Sadler's laboratory. In this account we describe the discovery of thiolato-bridged dinuclear arene ruthenium complexes and highlight subsequent developments in the field, including their syntheses, structures, and the recent strategies for the design of thiolato-bridged dinuclear arene ruthenium bioconjugates. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/73621/1/1-s2.0-S0010854515300436-main.pdf Furrer, Julien; Süss-Fink, Georg (2016). Thiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugs. Coordination Chemistry Reviews, 309, pp. 36-50. Elsevier 10.1016/j.ccr.2015.10.007 <http://dx.doi.org/10.1016/j.ccr.2015.10.007> doi:10.7892/boris.73621 info:doi:10.1016/j.ccr.2015.10.007 urn:issn:0010-8545 |
| Idioma(s) |
eng |
| Publicador |
Elsevier |
| Relação |
http://boris.unibe.ch/73621/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Furrer, Julien; Süss-Fink, Georg (2016). Thiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugs. Coordination Chemistry Reviews, 309, pp. 36-50. Elsevier 10.1016/j.ccr.2015.10.007 <http://dx.doi.org/10.1016/j.ccr.2015.10.007> |
| Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
