HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysis.
Data(s) |
2016
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Resumo |
HIV-infection is an important risk factor for developing Kaposi sarcoma (KS), but it is unclear whether HIV-positive persons are also at increased risk of co-infection with human herpesvirus 8 (HHV-8), the infectious cause of KS. We systematically searched literature up to December 2012 and included studies reporting HHV-8 seroprevalence for HIV-positive and HIV-negative persons. We used random-effects meta-analysis to combine odds ratios (ORs) of the association between HIV and HHV-8 seropositivity and conducted random-effects meta-regression to identify sources of heterogeneity. We included 93 studies with 58,357 participants from 32 countries in sub-Saharan Africa, North and South America, Europe, Asia, and Australia. Overall, HIV-positive persons were more likely to be HHV-8 seropositive than HIV-negative persons (OR 1.99, 95% confidence interval [CI] 1.70-2.34) with considerable heterogeneity among studies (I(2) 84%). The association was strongest in men who have sex with men (MSM, OR 3.95, 95% CI 2.92-5.35), patients with hemophilia (OR 3.11, 95% CI 1.19-8.11), and children (OR 2.45, 95% CI 1.58-3.81), but weaker in heterosexuals who engage in low-risk (OR 1.42, 95% CI 1.16-1.74) or high-risk sexual behavior (OR 1.66, 95% CI 1.27-2.17), persons who inject drugs (OR 1.66, 95% CI 1.28-2.14), and pregnant women (OR 1.68, 95% CI 1.15-2.47), p value for interaction <0.001. In conclusion, HIV-infection was associated with an increased HHV-8 seroprevalence in all population groups examined. A better understanding of HHV-8 transmission in different age and behavioral groups is needed to develop strategies to prevent HHV-8 transmission. |
Formato |
application/pdf application/pdf |
Identificador |
http://boris.unibe.ch/70950/2/Rohner%20IntJCancer%202015_supplmat.pdf http://boris.unibe.ch/70950/13/Rohner%20IntJCancer%202016.pdf Rohner, Eliane; Wyss, Natascha; Heg, Zina; Faralli, Zully; Mbulaiteye, Sam M; Novak, Urban; Zwahlen, Marcel; Egger, Matthias; Bohlius, Julia (2016). HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysis. International journal of cancer, 138(1), pp. 45-54. Wiley-Blackwell 10.1002/ijc.29687 <http://dx.doi.org/10.1002/ijc.29687> doi:10.7892/boris.70950 info:doi:10.1002/ijc.29687 info:pmid:26175054 urn:issn:0020-7136 |
Idioma(s) |
eng |
Publicador |
Wiley-Blackwell |
Relação |
http://boris.unibe.ch/70950/ |
Direitos |
info:eu-repo/semantics/restrictedAccess info:eu-repo/semantics/restrictedAccess |
Fonte |
Rohner, Eliane; Wyss, Natascha; Heg, Zina; Faralli, Zully; Mbulaiteye, Sam M; Novak, Urban; Zwahlen, Marcel; Egger, Matthias; Bohlius, Julia (2016). HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysis. International journal of cancer, 138(1), pp. 45-54. Wiley-Blackwell 10.1002/ijc.29687 <http://dx.doi.org/10.1002/ijc.29687> |
Palavras-Chave | #610 Medicine & health #360 Social problems & social services |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |