A mutation in hairless dogs implicates FOXI3 in ectodermal development
| Data(s) |
12/09/2008
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|---|---|
| Resumo |
Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/70772/1/1462.full.pdf Drögemüller, Cord; Karlsson, Elinor K; Hytönen, Marjo K; Perloski, Michele; Dolf, Gaudenz; Sainio, Kirsi; Lohi, Hannes; Lindblad-Toh, Kerstin; Leeb, Tosso (2008). A mutation in hairless dogs implicates FOXI3 in ectodermal development. Science, 321(5895), p. 1462. American Association for the Advancement of Science 10.1126/science.1162525 <http://dx.doi.org/10.1126/science.1162525> doi:10.7892/boris.70772 info:doi:10.1126/science.1162525 info:pmid:18787161 urn:issn:0036-8075 |
| Idioma(s) |
eng |
| Publicador |
American Association for the Advancement of Science |
| Relação |
http://boris.unibe.ch/70772/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Drögemüller, Cord; Karlsson, Elinor K; Hytönen, Marjo K; Perloski, Michele; Dolf, Gaudenz; Sainio, Kirsi; Lohi, Hannes; Lindblad-Toh, Kerstin; Leeb, Tosso (2008). A mutation in hairless dogs implicates FOXI3 in ectodermal development. Science, 321(5895), p. 1462. American Association for the Advancement of Science 10.1126/science.1162525 <http://dx.doi.org/10.1126/science.1162525> |
| Palavras-Chave | #570 Life sciences; biology #590 Animals (Zoology) #610 Medicine & health |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
