Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells
| Data(s) |
2015
|
|---|---|
| Resumo |
In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil samples. SENP5 is an enzyme that targets and cleaves small ubiquitin-like modifier (SUMO) residues from SUMOylated proteins. Further investigation with AML neutrophil differentiation cell models showed increased SENP5 expression upon induction of differentiation; in contrast, knocking down SENP5 resulted in significantly attenuated neutrophil differentiation. Our results support a new role of SENP5 in AML pathology, and in particular in the neutrophil differentiation of myeloid leukemic cells. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/70313/1/1-s2.0-S2213048914200112-main.pdf Federzoni, Elena; Gloor, Severin; Jin, Jing; Krauer, Deborah; Fey, Martin; Torbett, Bruce E; Tschan, Mario (2015). Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. Leukemia Research Reports, 4(1), pp. 32-35. Elsevier 10.1016/j.lrr.2015.04.002 <http://dx.doi.org/10.1016/j.lrr.2015.04.002> doi:10.7892/boris.70313 info:doi:10.1016/j.lrr.2015.04.002 info:pmid:25984443 urn:issn:2213-0489 |
| Idioma(s) |
eng |
| Publicador |
Elsevier |
| Relação |
http://boris.unibe.ch/70313/ |
| Direitos |
info:eu-repo/semantics/openAccess |
| Fonte |
Federzoni, Elena; Gloor, Severin; Jin, Jing; Krauer, Deborah; Fey, Martin; Torbett, Bruce E; Tschan, Mario (2015). Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. Leukemia Research Reports, 4(1), pp. 32-35. Elsevier 10.1016/j.lrr.2015.04.002 <http://dx.doi.org/10.1016/j.lrr.2015.04.002> |
| Palavras-Chave | #610 Medicine & health |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
