Inflammatory, immunological, and intestinal disease biomarkers in Chinese Shar-Pei dogs with marked hypocobalaminemia.
Data(s) |
04/02/2015
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Resumo |
Chinese Shar-Pei dogs have a high prevalence of hypocobalaminemia and are commonly presented with clinical signs suggestive of severe and long-standing gastrointestinal disease such as diarrhea, vomiting, and/or weight loss. The aim of the current study was to evaluate serum concentrations of inflammatory markers, markers for intestinal disease, and immunological markers in Shar-Peis with hypocobalaminemia or normocobalaminemia (serum cobalamin concentrations within the reference interval). Serum samples from Shar-Peis were collected from various parts of the United States. Serum concentrations of inflammatory markers (i.e., C-reactive protein [CRP], calprotectin [CP], and S100A12), hyaluronic acid (HA, a marker for cutaneous mucinosis), and analytes commonly altered in chronic intestinal diseases (i.e., albumin, zinc, alpha1-proteinease inhibitor [α1PI], immunoglobulin [Ig]A, and IgM) were compared between Shar-Peis with hypocobalaminemia and Shar-Peis with normocobalaminemia. Serum concentrations of CRP, CP, S100A12, HA, zinc, and cα1-PI concentrations did not differ between hypocobalaminemic and normocobalaminemic Shar-Peis (P > 0.05). Serum concentrations of albumin were significantly lower in hypocobalaminemic Shar-Peis (median: 2.5 g/dl) than in normocobalaminemic Shar-Peis (median: 2.9 g/dl; P < 0.0001). Higher serum IgA concentrations and lower serum IgM concentrations were observed in hypocobalaminemic Shar-Peis (median: 1.7 g/l and 0.8 g/l, respectively) than in normocobalaminemic Shar-Peis (median: 0.7 g/l and 1.9 g/l, respectively; both P < 0.0001). In conclusion, no difference was found in serum concentrations of CRP, CP, S100A12, and HA between hypocobalaminemic and normocobalaminemic Shar-Peis whereas some differences were observed in analytes (e.g., albumin, IgA, and IgM) that may be altered in patients with chronic enteropathies. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/69102/1/31.full.pdf Grützner, Niels; Heilmann, Romy M; Cranford, Shannon M; Holzenburg, Andreas; Suchodolski, Jan S; Steiner, Jörg M (2015). Inflammatory, immunological, and intestinal disease biomarkers in Chinese Shar-Pei dogs with marked hypocobalaminemia. Journal of veterinary diagnostic investigation, 27(1), pp. 31-40. American Association of Veterinary Laboratory Diagnosticians AAVLD 10.1177/1040638714560881 <http://dx.doi.org/10.1177/1040638714560881> doi:10.7892/boris.69102 info:doi:10.1177/1040638714560881 info:pmid:25525135 urn:issn:1040-6387 |
Idioma(s) |
eng |
Publicador |
American Association of Veterinary Laboratory Diagnosticians AAVLD |
Relação |
http://boris.unibe.ch/69102/ |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Grützner, Niels; Heilmann, Romy M; Cranford, Shannon M; Holzenburg, Andreas; Suchodolski, Jan S; Steiner, Jörg M (2015). Inflammatory, immunological, and intestinal disease biomarkers in Chinese Shar-Pei dogs with marked hypocobalaminemia. Journal of veterinary diagnostic investigation, 27(1), pp. 31-40. American Association of Veterinary Laboratory Diagnosticians AAVLD 10.1177/1040638714560881 <http://dx.doi.org/10.1177/1040638714560881> |
Palavras-Chave | #610 Medicine & health |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |