DNA binding properties of oligodeoxynucleotides containing pyrrolidino C-nucleosides
| Data(s) |
2002
|
|---|---|
| Resumo |
We have incorporated pyrrolidino-C-nucleosides (pyrrolidino-pseudonucleosides) containing the base uracil and N-1-methyl uracil into oligodeoxynucleotides and compared their thermal duplex and triplex stabilities with unmodified or pseudouridine-containing oligodeoxynucleotides. We find relative destabilizations of triplex formation by ca. -13 to -1 degrees C per modification (relative to thymidine) in a strongly sequence dependent mode. Duplex formation is less destabilizing and more homogeneous with -4 to -2 degrees C per modification |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/68582/1/reprint.pdf Häberli, A.; Leumann, Christian (2002). DNA binding properties of oligodeoxynucleotides containing pyrrolidino C-nucleosides. Organic letters, 4(19), pp. 3275-3278. American Chemical Society 10.1021/ol026537u <http://dx.doi.org/10.1021/ol026537u> doi:10.7892/boris.68582 info:doi:10.1021/ol026537u info:pmid:12227767 urn:issn:1523-7060 |
| Idioma(s) |
eng |
| Publicador |
American Chemical Society |
| Relação |
http://boris.unibe.ch/68582/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Häberli, A.; Leumann, Christian (2002). DNA binding properties of oligodeoxynucleotides containing pyrrolidino C-nucleosides. Organic letters, 4(19), pp. 3275-3278. American Chemical Society 10.1021/ol026537u <http://dx.doi.org/10.1021/ol026537u> |
| Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
