Synthesis of a cyclopentane amide DNA analogue and its base pairing properties
| Data(s) |
2003
|
|---|---|
| Resumo |
cpa-DNA monomers containing the bases adenine and thymine have been synthesized starting from the known compound 1 in 12 steps. Partially and fully modified cpa-thymidine and cpa-adenosine containing oligodeoxynucleotides were synthesized by standard oligonucleotide chemistry. Fully modified homo-cpa-A sequences lead to duplex destabilization by -1.4 degrees C/mod. relative to DNA. As its congener bca-DNA, cpa-DNA prefers left-handed duplex formation where possible |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/68575/1/10833737.pdf Ahn, D. R.; Mosimann, Markus; Leumann, Christian (2003). Synthesis of a cyclopentane amide DNA analogue and its base pairing properties. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1207-1210. Taylor & Francis 10.1081/NCN-120022837 <http://dx.doi.org/10.1081/NCN-120022837> doi:10.7892/boris.68575 info:doi:10.1081/NCN-120022837 urn:issn:1525-7770 |
| Idioma(s) |
eng |
| Publicador |
Taylor & Francis |
| Relação |
http://boris.unibe.ch/68575/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Ahn, D. R.; Mosimann, Markus; Leumann, Christian (2003). Synthesis of a cyclopentane amide DNA analogue and its base pairing properties. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1207-1210. Taylor & Francis 10.1081/NCN-120022837 <http://dx.doi.org/10.1081/NCN-120022837> |
| Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
