Transition metal ligands as novel DNA-base substitutes
| Data(s) |
2003
|
|---|---|
| Resumo |
The base modified nucleoside dBP, carrying a non-hydrogen-bonding non-shape complementary base was incorporated into oligonucleotides (Brotschi, C.; Haberli, A.; Leumann C.J. Angew. Chem. Int. Ed. 2001, 40, 3012-3014). This base was designed to coordinate transition metal ions into well defined positions within a DNA double helix. Melting experiments revealed that the stability of a dBP:dBP base couple in a DNA duplex is similar to a dG:dC base pair even in the absence of transition metal ions. In the presence of transition metal ions, melting experiments revealed a decrease in duplex stability which is on a similar order for all metal ions (Mn2+, Cu2+, Zn2+, Ni2+) tested |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/68571/1/10833740.pdf Brotschi, C.; Leumann, Christian (2003). Transition metal ligands as novel DNA-base substitutes. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1195-1197. Taylor & Francis 10.1081/NCN-120022834 <http://dx.doi.org/10.1081/NCN-120022834> doi:10.7892/boris.68571 info:doi:10.1081/NCN-120022834 info:pmid:14565378 urn:issn:1525-7770 |
| Idioma(s) |
eng |
| Publicador |
Taylor & Francis |
| Relação |
http://boris.unibe.ch/68571/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Brotschi, C.; Leumann, Christian (2003). Transition metal ligands as novel DNA-base substitutes. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1195-1197. Taylor & Francis 10.1081/NCN-120022834 <http://dx.doi.org/10.1081/NCN-120022834> |
| Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
