Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances


Autoria(s): Mani, Jan; Desy, Silvia Franziska; Niemann, Moritz; Chanfon, Astrid; Oeljeklaus, Silke; Pusnik, Mascha; Schmidt, Oliver; Gerbeth, Carolin; Meisinger, Chris; Warscheid, Bettina; Schneider, André
Data(s)

26/03/2015

Resumo

Mitochondrial protein import is essential for all eukaryotes and mediated by hetero-oligomeric protein translocases thought to be conserved within all eukaryotes. We have identified and analysed the function and architecture of the non-conventional outer membrane (OM) protein translocase in the early diverging eukaryote Trypanosoma brucei. It consists of six subunits that show no obvious homology to translocase components of other species. Two subunits are import receptors that have a unique topology and unique protein domains and thus evolved independently of the prototype receptors ​Tom20 and ​Tom70. Our study suggests that protein import receptors were recruited to the core of the OM translocase after the divergence of the major eukaryotic supergroups. Moreover, it links the evolutionary history of mitochondrial protein import receptors to the origin of the eukaryotic supergroups.

Formato

application/pdf

Identificador

http://boris.unibe.ch/67011/1/ncomms7646.pdf

Mani, Jan; Desy, Silvia Franziska; Niemann, Moritz; Chanfon, Astrid; Oeljeklaus, Silke; Pusnik, Mascha; Schmidt, Oliver; Gerbeth, Carolin; Meisinger, Chris; Warscheid, Bettina; Schneider, André (2015). Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances. Nature communications, 6(6646), p. 6646. Nature Publishing Group 10.1038/ncomms7646 <http://dx.doi.org/10.1038/ncomms7646>

doi:10.7892/boris.67011

info:doi:10.1038/ncomms7646

urn:issn:2041-1723

Idioma(s)

eng

Publicador

Nature Publishing Group

Relação

http://boris.unibe.ch/67011/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Mani, Jan; Desy, Silvia Franziska; Niemann, Moritz; Chanfon, Astrid; Oeljeklaus, Silke; Pusnik, Mascha; Schmidt, Oliver; Gerbeth, Carolin; Meisinger, Chris; Warscheid, Bettina; Schneider, André (2015). Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances. Nature communications, 6(6646), p. 6646. Nature Publishing Group 10.1038/ncomms7646 <http://dx.doi.org/10.1038/ncomms7646>

Palavras-Chave #570 Life sciences; biology #540 Chemistry
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed