Current concepts: host-pathogen interactions in cystic fibrosis airways disease.


Autoria(s): Tang, Anthony C; Turvey, Stuart E; Alves, Marco; Regamey, Nicolas; Tümmler, Burkhard; Hartl, Dominik
Data(s)

01/09/2014

Resumo

Chronic infection and inflammation are defining characteristics of cystic fibrosis (CF) airway disease. Conditions within the airways of patients living with CF are conducive to colonisation by a variety of opportunistic bacterial, viral and fungal pathogens. Improved molecular identification of microorganisms has begun to emphasise the polymicrobial nature of infections in the CF airway microenvironment. Changes to CF airway physiology through loss of cystic fibrosis transmembrane conductance regulator functionality result in a wide range of immune dysfunctions, which permit pathogen colonisation and persistence. This review will summarise the current understanding of how CF pathogens infect, interact with and evade the CF host.

Formato

application/pdf

Identificador

http://boris.unibe.ch/66607/1/320.full.pdf

Tang, Anthony C; Turvey, Stuart E; Alves, Marco; Regamey, Nicolas; Tümmler, Burkhard; Hartl, Dominik (2014). Current concepts: host-pathogen interactions in cystic fibrosis airways disease. European respiratory review, 23(133), pp. 320-332. European Respiratory Society 10.1183/09059180.00006113 <http://dx.doi.org/10.1183/09059180.00006113>

doi:10.7892/boris.66607

info:doi:10.1183/09059180.00006113

info:pmid:25176968

urn:issn:0905-9180

Idioma(s)

eng

Publicador

European Respiratory Society

Relação

http://boris.unibe.ch/66607/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Tang, Anthony C; Turvey, Stuart E; Alves, Marco; Regamey, Nicolas; Tümmler, Burkhard; Hartl, Dominik (2014). Current concepts: host-pathogen interactions in cystic fibrosis airways disease. European respiratory review, 23(133), pp. 320-332. European Respiratory Society 10.1183/09059180.00006113 <http://dx.doi.org/10.1183/09059180.00006113>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed