Asthma and obesity in children: current evidence and potential systems biology approaches.


Autoria(s): Frey, Ulrich; Latzin, Philipp; Usemann, J; Maccora, J; Zumsteg, U; Kriemler, S
Data(s)

01/01/2015

Resumo

Both obesity and asthma are highly prevalent, complex diseases modified by multiple factors. Genetic, developmental, lung mechanical, immunological and behavioural factors have all been suggested as playing a causal role between the two entities; however, their complex mechanistic interactions are still poorly understood and evidence of causality in children remains scant. Equally lacking is evidence of effective treatment strategies, despite the fact that imbalances at vulnerable phases in childhood can impact long-term health. This review is targeted at both clinicians frequently faced with the dilemma of how to investigate and treat the obese asthmatic child and researchers interested in the topic. Highlighting the breadth of the spectrum of factors involved, this review collates evidence regarding the investigation and treatment of asthma in obese children, particularly in comparison with current approaches in 'difficult-to-treat' childhood asthma. Finally, the authors propose hypotheses for future research from a systems-based perspective.

Formato

application/pdf

Identificador

http://boris.unibe.ch/66593/1/all12525.pdf

Frey, Ulrich; Latzin, Philipp; Usemann, J; Maccora, J; Zumsteg, U; Kriemler, S (2015). Asthma and obesity in children: current evidence and potential systems biology approaches. Allergy, 70(1), pp. 26-40. Wiley-Blackwell 10.1111/all.12525 <http://dx.doi.org/10.1111/all.12525>

doi:10.7892/boris.66593

info:doi:10.1111/all.12525

info:pmid:25236686

urn:issn:0105-4538

Idioma(s)

eng

Publicador

Wiley-Blackwell

Relação

http://boris.unibe.ch/66593/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Frey, Ulrich; Latzin, Philipp; Usemann, J; Maccora, J; Zumsteg, U; Kriemler, S (2015). Asthma and obesity in children: current evidence and potential systems biology approaches. Allergy, 70(1), pp. 26-40. Wiley-Blackwell 10.1111/all.12525 <http://dx.doi.org/10.1111/all.12525>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed