BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance.
| Data(s) |
15/02/2015
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| Resumo |
Pan- or multidrug resistance is a central problem in clinical oncology. Here, we use a genetically engineered mouse model of BRCA2-associated hereditary breast cancer to study drug resistance to several types of chemotherapy and PARP inhibition. We found that multidrug resistance was strongly associated with an EMT-like sarcomatoid phenotype and high expression of the Abcb1b gene, which encodes the drug efflux transporter P-glycoprotein. Inhibition of P-glycoprotein could partly resensitize sarcomatoid tumors to the PARP inhibitor olaparib, docetaxel, and doxorubicin. We propose that multidrug resistance is a multifactorial process and that mouse models are useful to unravel this. Cancer Res; 75(4); 732-41. ©2014 AACR. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/66319/1/Cancer%20Res-2015-Jaspers-732-41.pdf Jaspers, Janneke E; Sol, Wendy; Kersbergen, Ariena; Schlicker, Andreas; Guyader, Charlotte; Xu, Guotai; Wessels, Lodewyk; Borst, Piet; Jonkers, Jos; Rottenberg, Sven (2015). BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance. Cancer research, 75(4), pp. 732-741. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-14-0839 <http://dx.doi.org/10.1158/0008-5472.CAN-14-0839> doi:10.7892/boris.66319 info:doi:10.1158/0008-5472.CAN-14-0839 info:pmid:25511378 urn:issn:0008-5472 |
| Idioma(s) |
eng |
| Publicador |
American Association for Cancer Research AACR |
| Relação |
http://boris.unibe.ch/66319/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Jaspers, Janneke E; Sol, Wendy; Kersbergen, Ariena; Schlicker, Andreas; Guyader, Charlotte; Xu, Guotai; Wessels, Lodewyk; Borst, Piet; Jonkers, Jos; Rottenberg, Sven (2015). BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance. Cancer research, 75(4), pp. 732-741. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-14-0839 <http://dx.doi.org/10.1158/0008-5472.CAN-14-0839> |
| Palavras-Chave | #630 Agriculture |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
