Colostrogenesis: IgG1 Transcytosis Mechanisms


Autoria(s): Baumrucker, Craig; Bruckmaier, Rupert
Data(s)

01/03/2014

Resumo

Biological transport of intact proteins across epithelial cells has been documented for many absorptive and secretory tissues. Immunoglobulins were some of the earliest studied proteins in this category. The transcellular transport (transcytosis) of immunoglobulins in neonatal health and development has been recognized; the process is especially significant with ungulates because they do not transcytose immunoglobulins across the placenta to the neonate. Rather, they depend upon mammary secretion of colostrum and intestinal absorption of immunoglobulins in order to provide intestinal and systemic defense until the young ungulate develops its own humoral defense mechanisms. The neonatal dairy calf's ability to absorb immunoglobulins from colostrum is assisted by a ~24 h "open gut" phenomenon where large proteins pass the intestinal epithelial cells and enter the systemic system. However, a critical problem recognized for newborn dairy calves is that an optimum mass of colostrum Immunoglobulin G (IgG) needs to be absorbed within that 24 h window in order to provide maximal resistance to disease. Many calves do not achieve the optimum because of poor quality colostrum. While many studies have focused on calf absorption, the principal cause of the problem resides with the extreme variation (g to kg) in the mammary gland's capacity to transfer blood IgG1 into colostrum. Colostrum is a unique mammary secretory product that is formed during late pregnancy when mammary cells are proliferating and differentiating in preparation for lactation. In addition to the transcytosis of immunoglobulins, the mammary gland also concentrates a number of circulating hormones into colostrum. Remarkably, the mechanisms in the formation of colostrum in ungulates have been rather modestly studied. The mechanisms and causes of this variation in mammary gland transcytosis of IgG1 are examined, evaluated, and in some cases, explained

Formato

application/pdf

Identificador

http://boris.unibe.ch/66017/1/art%253A10.1007%252Fs10911-013-9313-5.pdf

Baumrucker, Craig; Bruckmaier, Rupert (2014). Colostrogenesis: IgG1 Transcytosis Mechanisms. Journal of mammary gland biology and neoplasia, 19(1), pp. 103-117. Springer 10.1007/s10911-013-9313-5 <http://dx.doi.org/10.1007/s10911-013-9313-5>

doi:10.7892/boris.66017

info:doi:10.1007/s10911-013-9313-5

info:pmid:24474529

urn:issn:1083-3021

Idioma(s)

eng

Publicador

Springer

Relação

http://boris.unibe.ch/66017/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Baumrucker, Craig; Bruckmaier, Rupert (2014). Colostrogenesis: IgG1 Transcytosis Mechanisms. Journal of mammary gland biology and neoplasia, 19(1), pp. 103-117. Springer 10.1007/s10911-013-9313-5 <http://dx.doi.org/10.1007/s10911-013-9313-5>

Palavras-Chave #610 Medicine & health #630 Agriculture
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed