Use of diuretics and risk of incident gout: a population-based case-control study


Autoria(s): Bruderer, Saskia; Bodmer, Michael; Jick, Susan S; Meier, Christoph R
Data(s)

01/01/2014

Resumo

OBJECTIVE Use of diuretics has been associated with an increased risk of gout. Data on different types of diuretics are scarce. We undertook this study to investigate the association between use of loop diuretics, thiazide or thiazide-like diuretics, and potassium-sparing agents and the risk of developing incident gout. METHODS We conducted a retrospective population-based case-control analysis using the General Practice Research Database established in the UK. We identified case patients who were diagnosed as having incident gout between 1990 and 2010. One control patient was matched to each case patient for age, sex, general practice, calendar time, and years of active history in the database. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs), and we adjusted for potential confounders. RESULTS We identified 91,530 incident cases of gout and the same number of matched controls. Compared to past use of diuretics from each respective drug class, adjusted ORs for current use of loop diuretics, thiazide diuretics, thiazide-like diuretics, and potassium-sparing diuretics were 2.64 (95% CI 2.47-2.83), 1.70 (95% CI 1.62-1.79), 2.30 (95% CI 1.95-2.70), and 1.06 (95% CI 0.91-1.23), respectively. Combined use of loop diuretics and thiazide diuretics was associated with the highest relative risk estimates of gout (adjusted OR 4.65 [95% CI 3.51-6.16]). Current use of calcium channel blockers or losartan slightly attenuated the risk of gout in patients who took diuretics. CONCLUSION Use of loop diuretics, thiazide diuretics, and thiazide-like diuretics was associated with an increased risk of incident gout, although use of potassium-sparing agents was not.

Formato

application/pdf

Identificador

http://boris.unibe.ch/65208/1/art38203.pdf

Bruderer, Saskia; Bodmer, Michael; Jick, Susan S; Meier, Christoph R (2014). Use of diuretics and risk of incident gout: a population-based case-control study. Arthritis & rheumatology, 66(1), pp. 185-196. Wiley-Blackwell 10.1002/art.38203 <http://dx.doi.org/10.1002/art.38203>

doi:10.7892/boris.65208

info:doi:10.1002/art.38203

info:pmid:24449584

urn:issn:2326-5205

Idioma(s)

eng

Publicador

Wiley-Blackwell

Relação

http://boris.unibe.ch/65208/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Bruderer, Saskia; Bodmer, Michael; Jick, Susan S; Meier, Christoph R (2014). Use of diuretics and risk of incident gout: a population-based case-control study. Arthritis & rheumatology, 66(1), pp. 185-196. Wiley-Blackwell 10.1002/art.38203 <http://dx.doi.org/10.1002/art.38203>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed