Support of hepatic regeneration by trophic factors from liver-derived mesenchymal stromal/stem cells
| Data(s) |
04/08/2014
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| Resumo |
Mesenchymal stromal/stem cells (MSCs) have multilineage differentiation potential and as such are known to promote regeneration in response to tissue injury. However, accumulating evidence indicates that the regenerative capacity of MSCs is not via transdifferentiation but mediated by their production of trophic and other factors that promote endogenous regeneration pathways of the tissue cells. In this chapter, we provide a detailed description on how to obtain trophic factors secreted by cultured MSCs and how they can be used in small animal models. More specific, in vivo models to study the paracrine effects of MSCs on regeneration of the liver after surgical resection and/or ischemia and reperfusion injury are described. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/64711/1/chp%253A10.1007%252F978-1-4939-1453-1_9.pdf Fouraschen, Suomi M G; Hall, Sean; de Jonge, Jeroen; van der Laan, Luc J W (2014). Support of hepatic regeneration by trophic factors from liver-derived mesenchymal stromal/stem cells. Methods in molecular biology, 1213, pp. 89-104. Humana Press 10.1007/978-1-4939-1453-1_9 <http://dx.doi.org/10.1007/978-1-4939-1453-1_9> doi:10.7892/boris.64711 info:doi:10.1007/978-1-4939-1453-1_9 info:pmid:25173377 urn:issn:1064-3745 |
| Idioma(s) |
eng |
| Publicador |
Humana Press |
| Relação |
http://boris.unibe.ch/64711/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Fouraschen, Suomi M G; Hall, Sean; de Jonge, Jeroen; van der Laan, Luc J W (2014). Support of hepatic regeneration by trophic factors from liver-derived mesenchymal stromal/stem cells. Methods in molecular biology, 1213, pp. 89-104. Humana Press 10.1007/978-1-4939-1453-1_9 <http://dx.doi.org/10.1007/978-1-4939-1453-1_9> |
| Palavras-Chave | #610 Medicine & health |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
