Discovery of a highly potent anti-inflammatory epoxyisoprostane-derived lactone.
| Data(s) |
17/12/2014
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|---|---|
| Resumo |
Epoxyisoprostanes EI (1) and EC (2) are effective inhibitors of the secretion of proinflammatory cytokines IL-6 and IL-12. In detailed studies toward the investigation of the molecular mode of action of these structures, a highly potent lactone (3) derived from 1 was identified. The known isoprostanoids 1 and 2 are most likely precursors of 3, the product of facile intramolecular reaction between the epoxide with the carboxylic acid in 2. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/63561/1/ja509892u.pdf Egger, Julian; Bretscher, Peter; Freigang, Stefan Bernd; Kopf, Manfred; Carreira, Erick M (2014). Discovery of a highly potent anti-inflammatory epoxyisoprostane-derived lactone. Journal of the American Chemical Society, 136(50), pp. 17382-17385. American Chemical Society 10.1021/ja509892u <http://dx.doi.org/10.1021/ja509892u> doi:10.7892/boris.63561 info:doi:10.1021/ja509892u info:pmid:25474746 urn:issn:0002-7863 |
| Idioma(s) |
eng |
| Publicador |
American Chemical Society |
| Relação |
http://boris.unibe.ch/63561/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Egger, Julian; Bretscher, Peter; Freigang, Stefan Bernd; Kopf, Manfred; Carreira, Erick M (2014). Discovery of a highly potent anti-inflammatory epoxyisoprostane-derived lactone. Journal of the American Chemical Society, 136(50), pp. 17382-17385. American Chemical Society 10.1021/ja509892u <http://dx.doi.org/10.1021/ja509892u> |
| Palavras-Chave | #570 Life sciences; biology #610 Medicine & health |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
