Endothelial binding of beta toxin to small intestinal mucosal endothelial cells in early stages of experimentally induced Clostridium perfringens type C enteritis in pigs.


Autoria(s): Schumacher, Vanessa; Martel, A; Pasmans, F; Van Immerseel, F; Posthaus, Horst
Data(s)

01/07/2013

Resumo

Beta toxin (CPB) is known to be an essential virulence factor in the development of lesions of Clostridium perfringens type C enteritis in different animal species. Its target cells and exact mechanism of toxicity have not yet been clearly defined. Here, we evaluate the suitability of a neonatal piglet jejunal loop model to investigate early lesions of C. perfringens type C enteritis. Immunohistochemically, CPB was detected at microvascular endothelial cells in intestinal villi during early and advanced stages of lesions induced by C. perfringens type C. This was first associated with capillary dilatation and subsequently with widespread hemorrhage in affected intestinal segments. CPB was, however, not demonstrated on intestinal epithelial cells. This indicates a tropism of CPB toward endothelial cells and suggests that CPB-induced endothelial damage plays an important role in the early stages of C. perfringens type C enteritis in pigs.

Formato

application/pdf

Identificador

http://boris.unibe.ch/63151/1/Vet%20Pathol-2013-Schumacher-626-9.pdf

Schumacher, Vanessa; Martel, A; Pasmans, F; Van Immerseel, F; Posthaus, Horst (2013). Endothelial binding of beta toxin to small intestinal mucosal endothelial cells in early stages of experimentally induced Clostridium perfringens type C enteritis in pigs. Veterinary pathology, 50(4), pp. 626-629. American College of Veterinary Pathologists 10.1177/0300985812461362 <http://dx.doi.org/10.1177/0300985812461362>

doi:10.7892/boris.63151

info:doi:10.1177/0300985812461362

info:pmid:23012387

urn:issn:0300-9858

Idioma(s)

eng

Publicador

American College of Veterinary Pathologists

Relação

http://boris.unibe.ch/63151/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Schumacher, Vanessa; Martel, A; Pasmans, F; Van Immerseel, F; Posthaus, Horst (2013). Endothelial binding of beta toxin to small intestinal mucosal endothelial cells in early stages of experimentally induced Clostridium perfringens type C enteritis in pigs. Veterinary pathology, 50(4), pp. 626-629. American College of Veterinary Pathologists 10.1177/0300985812461362 <http://dx.doi.org/10.1177/0300985812461362>

Palavras-Chave #630 Agriculture
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed