Cell therapy for intervertebral disc repair: advancing cell therapy from bench to clinics


Autoria(s): Benneker, Lorin Michael; Anderson, G.; Iatridis, J C; Sakai, D; Härtl, R; Ito, K; Grad, S
Data(s)

2014

Resumo

Intervertebral disc (IVD) degeneration is a major cause of pain and disability; yet therapeutic options are limited and treatment often remains unsatisfactory. In recent years, research activities have intensified in tissue engineering and regenerative medicine, and pre-clinical studies have demonstrated encouraging results. Nonetheless, the translation of new biological therapies into clinical practice faces substantial barriers. During the symposium "Where Science meets Clinics", sponsored by the AO Foundation and held in Davos, Switzerland, from September 5-7, 2013, hurdles for translation were outlined, and ways to overcome them were discussed. With respect to cell therapy for IVD repair, it is obvious that regenerative treatment is indicated at early stages of disc degeneration, before structural changes have occurred. It is envisaged that in the near future, screening techniques and non-invasive imaging methods will be available to detect early degenerative changes. The promises of cell therapy include a sustained effect on matrix synthesis, inflammation control, and prevention of angio- and neuro-genesis. Discogenic pain, originating from "black discs" or annular injury, prevention of adjacent segment disease, and prevention of post-discectomy syndrome were identified as prospective indications for cell therapy. Before such therapy can safely and effectively be introduced into clinics, the identification of the patient population and proper standardisation of diagnostic parameters and outcome measurements are indispensable. Furthermore, open questions regarding the optimal cell type and delivery method need to be resolved in order to overcome the safety concerns implied with certain procedures. Finally, appropriate large animal models and well-designed clinical studies will be required, particularly addressing safety aspects.

Formato

application/pdf

Identificador

http://boris.unibe.ch/62979/1/v027sa02.pdf

Benneker, Lorin Michael; Anderson, G.; Iatridis, J C; Sakai, D; Härtl, R; Ito, K; Grad, S (2014). Cell therapy for intervertebral disc repair: advancing cell therapy from bench to clinics. European cells & materials eCM, 27, pp. 5-11. University of Wales

doi:10.7892/boris.62979

info:pmid:24802611

urn:issn:1473-2262

Idioma(s)

eng

Publicador

University of Wales

Relação

http://boris.unibe.ch/62979/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Benneker, Lorin Michael; Anderson, G.; Iatridis, J C; Sakai, D; Härtl, R; Ito, K; Grad, S (2014). Cell therapy for intervertebral disc repair: advancing cell therapy from bench to clinics. European cells & materials eCM, 27, pp. 5-11. University of Wales

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed