Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes
| Data(s) |
2015
|
|---|---|
| Resumo |
In order to improve the water-solubility of dinuclear thiolato-bridged arene ruthenium complexes, a new series was synthesized by conjugating octaarginine, octalysine, and cyclo[Lys-Arg-Gly-Asp-D-Phe] using chloroacetyl thioether (ClAc) ligation, resulting in cytotoxic conjugates against A2780 human ovarian cancer cells (IC50 = 2–8 μM) and against the cisplatin resistant line A2780cisR (IC50 = 7–15 μM). These metal complexes represent, to the best of our knowledge, the most cytotoxic ruthenium bioconjugates reported so far. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/61886/1/c4md00433g.pdf Giannini, Federico; Bartoloni, Marco; Paul, Lydia E. H.; Süss-Fink, Georg; Reymond, Jean-Louis; Furrer, Julien (2015). Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes. Medicinal chemistry communications - MedChemComm, 6(2), pp. 347-350. Royal Society of Chemistry 10.1039/c4md00433g <http://dx.doi.org/10.1039/c4md00433g> doi:10.7892/boris.61886 info:doi:10.1039/c4md00433g urn:issn:2040-2503 |
| Idioma(s) |
eng |
| Publicador |
Royal Society of Chemistry |
| Relação |
http://boris.unibe.ch/61886/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Giannini, Federico; Bartoloni, Marco; Paul, Lydia E. H.; Süss-Fink, Georg; Reymond, Jean-Louis; Furrer, Julien (2015). Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes. Medicinal chemistry communications - MedChemComm, 6(2), pp. 347-350. Royal Society of Chemistry 10.1039/c4md00433g <http://dx.doi.org/10.1039/c4md00433g> |
| Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
