Impact of corneal cross-linking on topical drug penetration in humans.
Data(s) |
17/11/2014
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Resumo |
PURPOSE To analyse the influence of corneal cross-linking (CXL) with ultraviolet-A (UV-A) and riboflavin on drug permeability in human subjects. METHODS Keratoconus patients (n = 23; mean age 26.9 ± 5.8 years) undergoing a standard CXL procedure with UV-A (5.4 J/cm(2) , 30 min) and riboflavin in one eye were included in the study. The pupillary diameter, measured before and every 3 min for 30 min after the topical application of one drop of 2% pilocarpine, was used as an indirect measure of the corneal permeability. The pupillary diameter was measured with an infrared pupillometer device before (baseline) and 4 months after CXL. RESULTS Prior to pilocarpine application, no significant difference in the pupillary diameter was detected before CXL and 4 months later. The mean decrease in the pupillary diameter after the application of pilocarpine was similar at baseline and the 4-month follow-up visit: mean decreases of 3.9 and 3.7 mm were observed 30 min after pilocarpine application, respectively (p > 0.05). CONCLUSIONS No significant influence of CXL on the corneal penetration of topically applied pilocarpine was observed in this clinical study. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/61493/1/aos12595.pdf Tappeiner, Christoph; Tschopp, Markus; Schürch, Kaspar Werner; Früh Epstein, Beatrice (2014). Impact of corneal cross-linking on topical drug penetration in humans. Acta ophthalmologica, 93(5), e324-e327. Blackwell Munksgaard 10.1111/aos.12595 <http://dx.doi.org/10.1111/aos.12595> doi:10.7892/boris.61493 info:doi:10.1111/aos.12595 info:pmid:25402571 urn:issn:1755-375X |
Idioma(s) |
eng |
Publicador |
Blackwell Munksgaard |
Relação |
http://boris.unibe.ch/61493/ |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Tappeiner, Christoph; Tschopp, Markus; Schürch, Kaspar Werner; Früh Epstein, Beatrice (2014). Impact of corneal cross-linking on topical drug penetration in humans. Acta ophthalmologica, 93(5), e324-e327. Blackwell Munksgaard 10.1111/aos.12595 <http://dx.doi.org/10.1111/aos.12595> |
Palavras-Chave | #610 Medicine & health |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |