The Biological Side of Water-Soluble Arene Ruthenium Assemblies


Autoria(s): Therrien, Bruno; Furrer, Julien
Data(s)

2014

Resumo

This review article covers the synthetic strategies, structural aspects, and host-guest properties of ruthenium metalla-assemblies, with a special focus on their use as drug delivery vectors. The two-dimensional metalla-rectangles show interesting host-guest possibilities but seem less appropriate for being used as drug carriers. On the other hand, metalla-prisms allow encapsulation and possible targeted release of bioactive molecules and consequently show some potential as drug delivery vectors. The reactivity of these metalla-prisms can be fine-tuned to allow a fine control of the guest’s release. The larger metalla-cubes can be used to stabilize the formation of G-quadruplex DNA and can be used to encapsulate and release photoactive molecules such as porphins. These metalla-assemblies demonstrate great prospective in photodynamic therapy.

Formato

application/pdf

Identificador

http://boris.unibe.ch/58844/1/589686.pdf

Therrien, Bruno; Furrer, Julien (2014). The Biological Side of Water-Soluble Arene Ruthenium Assemblies. Advances in chemistry, 2014, pp. 1-20. Hindawi 10.1155/2014/589686 <http://dx.doi.org/10.1155/2014/589686>

doi:10.7892/boris.58844

info:doi:10.1155/2014/589686

urn:issn:2356-6612

Idioma(s)

eng

Publicador

Hindawi

Relação

http://boris.unibe.ch/58844/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Therrien, Bruno; Furrer, Julien (2014). The Biological Side of Water-Soluble Arene Ruthenium Assemblies. Advances in chemistry, 2014, pp. 1-20. Hindawi 10.1155/2014/589686 <http://dx.doi.org/10.1155/2014/589686>

Palavras-Chave #570 Life sciences; biology #540 Chemistry
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed