Levels of retinol and retinyl esters in plasma and urine of dogs with urolithiasis


Autoria(s): Raila, Jens; Forterre, Simone; Schweigert, F. J.
Data(s)

01/09/2003

Resumo

Vitamin A (VA) deficiency and Tamm-Horsfall glycoprotein (THP), a protein that binds retinol and retinyl esters in canine urine, might be involved in the pathogenesis of urolithiasis in dogs. In the present study, we assessed levels of retinol, retinyl esters, retinol-binding protein (RBP) and THP in plasma and urine of dogs with a history of urolithiasis (n = 25) compared with clinically healthy controls (n = 18). Plasma retinol concentrations were higher in dogs with uroliths of struvit (P < 0.01), calcium oxalate (P < 0.05), urate (P < 0.01) and cysteine, but there were no differences in the concentrations of plasma RBP and retinyl esters. Excretion of urinary retinol and retinyl esters were tentatively, but not significantly higher in the stone-forming groups, which was accompanied by increased levels of urinary RBP (P < 0.01) and lower excretions in THP (P < 0.01). The results show that VA deficiency may be excluded as a potential cause for canine urolithiasis. However, the occurrence of RBP and a concomitant reduction of THP in urine indicates a disturbed kidney function as cause or consequence of stone formation in dogs.

Formato

application/pdf

Identificador

http://boris.unibe.ch/58816/1/j.1439-0442.2003.00552.x.pdf

Raila, Jens; Forterre, Simone; Schweigert, F. J. (2003). Levels of retinol and retinyl esters in plasma and urine of dogs with urolithiasis. Journal of veterinary medicine. Series A - physiology, pathology, clinical medicine, 50(7), pp. 380-382. Blackwell 10.1046/j.1439-0442.2003.00552.x <http://dx.doi.org/10.1046/j.1439-0442.2003.00552.x>

doi:10.7892/boris.58816

info:doi:10.1046/j.1439-0442.2003.00552.x

info:pmid:14633234

urn:issn:0931-184X

Idioma(s)

eng

Publicador

Blackwell

Relação

http://boris.unibe.ch/58816/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Raila, Jens; Forterre, Simone; Schweigert, F. J. (2003). Levels of retinol and retinyl esters in plasma and urine of dogs with urolithiasis. Journal of veterinary medicine. Series A - physiology, pathology, clinical medicine, 50(7), pp. 380-382. Blackwell 10.1046/j.1439-0442.2003.00552.x <http://dx.doi.org/10.1046/j.1439-0442.2003.00552.x>

Palavras-Chave #610 Medicine & health #630 Agriculture
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed