Emergence of Klebsiella pneumoniae co-producing NDM-1, OXA-48, CTX-M-15, CMY-16, QnrA and ArmA in Switzerland
Data(s) |
23/06/2014
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Resumo |
Extensively drug-resistant (XDR) Klebsiella pneumoniae isolates usually carry a single carbapenemase (e.g. KPC, NDM, OXA-48-like). Here we describe an XDR K. pneumoniae of sequence type 101 that was detected in the screening rectal swab of a patient transferred from the intensive care unit of a hospital located in Belgrade (Serbia) to Bern University Hospital (Switzerland). The isolate was resistant to all antibiotics with the exception of colistin [minimum inhibitory concentration] (MIC≤0.125μg/mL), tigecycline (MIC=0.5μg/mL) and fosfomycin (MIC=2μg/mL). The isolate co-possessed class B (NDM-1) and class D (OXA-48) carbapenemases, class A extended-spectrum β-lactamase (CTX-M-15), class C cephalosporinase (CMY-16), ArmA 16S rRNA methyltransferase, substitutions in GyrA and ParC, loss of OmpK35 porin, as well as other genes conferring resistance to quinolones (qnrA), tetracyclines [tet(A)], sulfonamides (sul1, sul2), trimethoprim (dfrA12, dfrA14), rifampicin (arr-1), chloramphenicol (cmlA1, floR) and streptomycin (aadA1). The patient was placed under contact isolation precautions preventing the spread of this nearly untreatable pathogen. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/58156/1/Endimiani.pdf Seiffert, Salome Nadja; Marschall, Jonas; Perreten, Vincent; Carattoli, Alessandra; Furrer, Hansjakob; Endimiani, Andrea (2014). Emergence of Klebsiella pneumoniae co-producing NDM-1, OXA-48, CTX-M-15, CMY-16, QnrA and ArmA in Switzerland. International journal of antimicrobial agents, 44(3), pp. 260-262. Elsevier 10.1016/j.ijantimicag.2014.05.008 <http://dx.doi.org/10.1016/j.ijantimicag.2014.05.008> doi:10.7892/boris.58156 info:doi:10.1016/j.ijantimicag.2014.05.008 info:pmid:25123809 urn:issn:0924-8579 |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://boris.unibe.ch/58156/ |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Seiffert, Salome Nadja; Marschall, Jonas; Perreten, Vincent; Carattoli, Alessandra; Furrer, Hansjakob; Endimiani, Andrea (2014). Emergence of Klebsiella pneumoniae co-producing NDM-1, OXA-48, CTX-M-15, CMY-16, QnrA and ArmA in Switzerland. International journal of antimicrobial agents, 44(3), pp. 260-262. Elsevier 10.1016/j.ijantimicag.2014.05.008 <http://dx.doi.org/10.1016/j.ijantimicag.2014.05.008> |
Palavras-Chave | #570 Life sciences; biology #610 Medicine & health #630 Agriculture |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |