Synthesis and incorporation into DNA of a chemically stable, functional abasic site analogue
| Data(s) |
2005
|
|---|---|
| Resumo |
[reaction: see text] The abasic site building block 7 for DNA synthesis, containing a methylenephosphinic acid group at C3', was prepared in six steps and was incorporated into DNA via a combination of H-phosphonate and phosphoramidite chemistry. Corresponding oligodeoxynucleotides were shown to be chemically stable under basic conditions and fully functional at the respective hemiacetal center |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/53109/1/ol052045g.pdf Mosimann, Markus; Küpfer, Pascal A.; Leumann, Christian J. (2005). Synthesis and incorporation into DNA of a chemically stable, functional abasic site analogue. Organic letters, 7(23), pp. 5211-5214. American Chemical Society 10.1021/ol052045g <http://dx.doi.org/10.1021/ol052045g> doi:10.7892/boris.53109 info:doi:10.1021/ol052045g info:pmid:16268540 urn:issn:1523-7060 |
| Idioma(s) |
eng |
| Publicador |
American Chemical Society |
| Relação |
http://boris.unibe.ch/53109/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Mosimann, Markus; Küpfer, Pascal A.; Leumann, Christian J. (2005). Synthesis and incorporation into DNA of a chemically stable, functional abasic site analogue. Organic letters, 7(23), pp. 5211-5214. American Chemical Society 10.1021/ol052045g <http://dx.doi.org/10.1021/ol052045g> |
| Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
