RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes
| Data(s) |
2005
|
|---|---|
| Resumo |
Introduction of a hydrophobic biphenyl-C-nucleotide pair into a 11-mer RNA duplex is associated with a net penalty in the free energy of duplex formation of 2.0 kcal mol(-1) or 10 degrees C in T(m), relative to DNA. These differential stabilities are of relevance with respect to the transcriptional and translational aspects of hydrophobic base-pairs |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/53097/1/reprint.pdf Brotschi, Christine; Leumann, Christian J. (2005). RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes. Chemical communications(15), pp. 2023-2025. Royal Society of Chemistry 10.1039/B419278H <http://dx.doi.org/10.1039/B419278H> doi:10.7892/boris.53097 info:doi:10.1039/B419278H info:pmid:15834493 urn:issn:1359-7345 |
| Idioma(s) |
eng |
| Publicador |
Royal Society of Chemistry |
| Relação |
http://boris.unibe.ch/53097/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Brotschi, Christine; Leumann, Christian J. (2005). RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes. Chemical communications(15), pp. 2023-2025. Royal Society of Chemistry 10.1039/B419278H <http://dx.doi.org/10.1039/B419278H> |
| Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
