Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method.

Autoria(s): Ostrosky-Zeichner, Luis; Rex, John H; Pfaller, Michael A; Diekema, Daniel J; Alexander, Barbara D; Andes, David; Brown, Steven D; Chaturvedi, Vishnu; Ghannoum, Mahmoud A; Knapp, Cindy C; Sheehan, Daniel J; Walsh, Thomas J
Data(s)

01/11/2008
Resumo

We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.
Identificador

http://digitalcommons.library.tmc.edu/uthmed_docs/336

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573146/?tool=pmcentrez
Publicador

DigitalCommons@The Texas Medical Center
Fonte

UT Medical School Journal Articles
Palavras-Chave #Animals #Antifungal Agents #Candida #Candidiasis #Databases #Factual #Fluconazole #Humans #Microbial Sensitivity Tests #Models #Biological #Time Factors #Databases, Factual #Models, Biological #Medicine and Health Sciences
Tipo

text
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