Physiologic and hematologic concerns of rotary blood pumps: what needs to be improved?


Autoria(s): Pirbodaghi, Tohid; Asgari, Siavash; Cotter, Chris; Bourque, Kevin
Data(s)

01/03/2014

Resumo

Over the past few decades, advances in ventricular assist device (VAD) technology have provided a promising therapeutic strategy to treat heart failure patients. Despite the improved performance and encouraging clinical outcomes of the new generation of VADs based on rotary blood pumps (RBPs), their physiologic and hematologic effects are controversial. Currently, clinically available RBPs run at constant speed, which results in limited control over cardiac workload and introduces blood flow with reduced pulsatility into the circulation. In this review, we first provide an update on the new challenges of mechanical circulatory support using rotary pumps including blood trauma, increased non-surgical bleeding rate, limited cardiac unloading, vascular malformations, end-organ function, and aortic valve insufficiency. Since the non-physiologic flow characteristic of these devices is one of the main subjects of scientific debate in the literature, we next emphasize the latest research regarding the development of a pulsatile RBP. Finally, we offer an outlook for future research in the field.

Formato

application/pdf

Identificador

http://boris.unibe.ch/48024/1/art%253A10.1007%252Fs10741-013-9389-4.pdf

Pirbodaghi, Tohid; Asgari, Siavash; Cotter, Chris; Bourque, Kevin (2014). Physiologic and hematologic concerns of rotary blood pumps: what needs to be improved? Heart Failure Reviews, 19(2), pp. 259-266. Springer 10.1007/s10741-013-9389-4 <http://dx.doi.org/10.1007/s10741-013-9389-4>

doi:10.7892/boris.48024

info:doi:10.1007/s10741-013-9389-4

info:pmid:23549998

urn:issn:1382-4147

Idioma(s)

eng

Publicador

Springer

Relação

http://boris.unibe.ch/48024/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Pirbodaghi, Tohid; Asgari, Siavash; Cotter, Chris; Bourque, Kevin (2014). Physiologic and hematologic concerns of rotary blood pumps: what needs to be improved? Heart Failure Reviews, 19(2), pp. 259-266. Springer 10.1007/s10741-013-9389-4 <http://dx.doi.org/10.1007/s10741-013-9389-4>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed