Combining follow-up and change data is valid in meta-analyses of continuous outcomes: a meta-epidemiological study
Data(s) |
01/08/2013
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Resumo |
OBJECTIVE To investigate whether it is valid to combine follow-up and change data when conducting meta-analyses of continuous outcomes. STUDY DESIGN AND SETTING Meta-epidemiological study of randomized controlled trials in patients with osteoarthritis of the knee/hip, which assessed patient-reported pain. We calculated standardized mean differences (SMDs) based on follow-up and change data, and pooled within-trial differences in SMDs. We also derived pooled SMDs indicating the largest treatment effect within a trial (optimistic selection of SMDs) and derived pooled SMDs from the estimate indicating the smallest treatment effect within a trial (pessimistic selection of SMDs). RESULTS A total of 21 meta-analyses with 189 trials with 292 randomized comparisons in 41,256 patients were included. On average, SMDs were 0.04 standard deviation units more beneficial when follow-up values were used (difference in SMDs: -0.04; 95% confidence interval: -0.13, 0.06; P=0.44). In 13 meta-analyses (62%), there was a relevant difference in clinical and/or significance level between optimistic and pessimistic pooled SMDs. CONCLUSION On average, there is no relevant difference between follow-up and change data SMDs, and combining these estimates in meta-analysis is generally valid. Decision on which type of data to use when both follow-up and change data are available should be prespecified in the meta-analysis protocol. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/41066/1/DaCosta%20JClinEpidemiol%202013_p847.pdf Da Costa, Bruno R; Nüesch, Eveline; Rutjes, Anne W; Johnston, Bradley C; Reichenbach, Stephan; Trelle, Sven; Guyatt, Gordon H; Jüni, Peter (2013). Combining follow-up and change data is valid in meta-analyses of continuous outcomes: a meta-epidemiological study. Journal of clinical epidemiology, 66(8), pp. 847-55. Elsevier 10.1016/j.jclinepi.2013.03.009 <http://dx.doi.org/10.1016/j.jclinepi.2013.03.009> doi:10.7892/boris.41066 info:doi:10.1016/j.jclinepi.2013.03.009 info:pmid:23747228 urn:issn:0895-4356 |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://boris.unibe.ch/41066/ |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Da Costa, Bruno R; Nüesch, Eveline; Rutjes, Anne W; Johnston, Bradley C; Reichenbach, Stephan; Trelle, Sven; Guyatt, Gordon H; Jüni, Peter (2013). Combining follow-up and change data is valid in meta-analyses of continuous outcomes: a meta-epidemiological study. Journal of clinical epidemiology, 66(8), pp. 847-55. Elsevier 10.1016/j.jclinepi.2013.03.009 <http://dx.doi.org/10.1016/j.jclinepi.2013.03.009> |
Palavras-Chave | #610 Medicine & health #360 Social problems & social services |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |