Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials


Autoria(s): Pandis, Nikolaos; Walsh, Tanya; Polychronopoulou, Argy; Katsaros, Christos; Eliades, Theodore
Data(s)

01/12/2013

Resumo

SUMMARY Split-mouth designs first appeared in dental clinical trials in the late sixties. The main advantage of this study design is its efficiency in terms of sample size as the patients act as their own controls. Cited disadvantages relate to carry-across effects, contamination or spilling of the effects of one intervention to another, period effects if the interventions are delivered at different time periods, difficulty in finding similar comparison sites within patients and the requirement for more complex data analysis. Although some additional thought is required when utilizing a split-mouth design, the efficiency of this design is attractive, particularly in orthodontic clinical studies where carry-across, period effects and dissimilarity between intervention sites does not pose a problem. Selection of the appropriate research design, intervention protocol and statistical method accounting for both the reduced variability and potential clustering effects within patients should be considered for the trial results to be valid.

Formato

application/pdf

Identificador

http://boris.unibe.ch/39984/1/783.full.pdf

Pandis, Nikolaos; Walsh, Tanya; Polychronopoulou, Argy; Katsaros, Christos; Eliades, Theodore (2013). Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials. European journal of orthodontics, 35(6), pp. 783-789. Oxford University Press 10.1093/ejo/cjs108 <http://dx.doi.org/10.1093/ejo/cjs108>

doi:10.7892/boris.39984

info:doi:10.1093/ejo/cjs108

info:pmid:23376899

urn:issn:0141-5387

Idioma(s)

eng

Publicador

Oxford University Press

Relação

http://boris.unibe.ch/39984/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Pandis, Nikolaos; Walsh, Tanya; Polychronopoulou, Argy; Katsaros, Christos; Eliades, Theodore (2013). Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials. European journal of orthodontics, 35(6), pp. 783-789. Oxford University Press 10.1093/ejo/cjs108 <http://dx.doi.org/10.1093/ejo/cjs108>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed