Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β 2 subunit of GABA A receptors?
| Data(s) |
10/09/2013
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|---|---|
| Resumo |
NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors. NA-glycine has been suggested to act at the G-protein coupled receptors GPR18 and GPR92. Recently, we have described that NA-glycine can also modulate recombinant α1β2γ2 GABAA receptors. Here we characterize in more detail this modulation and investigate the relationship of its binding site with that of the endocannabinoid 2-AG. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/39561/1/peerj-149.pdf Baur, Roland; Gertsch, Jürg; Sigel, Erwin (2013). Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β 2 subunit of GABA A receptors? PeerJ, 1, e149. PeerJ, Ltd 10.7717/peerj.149 <http://dx.doi.org/10.7717/peerj.149> doi:10.7892/boris.39561 info:doi:10.7717/peerj.149 info:pmid:24058880 urn:issn:2167-8359 |
| Idioma(s) |
eng |
| Publicador |
PeerJ, Ltd |
| Relação |
http://boris.unibe.ch/39561/ |
| Direitos |
info:eu-repo/semantics/openAccess |
| Fonte |
Baur, Roland; Gertsch, Jürg; Sigel, Erwin (2013). Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β 2 subunit of GABA A receptors? PeerJ, 1, e149. PeerJ, Ltd 10.7717/peerj.149 <http://dx.doi.org/10.7717/peerj.149> |
| Palavras-Chave | #570 Life sciences; biology #610 Medicine & health |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
