Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae
| Data(s) |
2001
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|---|---|
| Resumo |
BACKGROUND: The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when strains show additional resistance to quinolones. The main objective of this study was to determine a treatment modality impeding the emergence of quinolone resistance. RESULTS: Exposure of a penicillin-resistant pneumococcus to increasing concentrations of trovafloxacin or ciprofloxacin selected for mutants resistant to these drugs. In the presence of sub-inhibitory concentrations of vancomycin, development of trovafloxacin-resistance and high-level ciprofloxacin-resistance were prevented. CONCLUSIONS: Considering the risk of quinolone-resistance in pneumococci, the observation might be of clinical importance. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/25740/1/7.pdf Cottagnoud, P; Entenza, JM; Cottagnoud, M; Que, YA; Moreillon, P; Taüber, MG (2001). Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae. BMC microbiology, 1(1), p. 9. London: BioMed Central 10.1186/1471-2180-1-9 <http://dx.doi.org/10.1186/1471-2180-1-9> doi:10.7892/boris.25740 info:doi:10.1186/1471-2180-1-9 info:pmid:11454238 urn:issn:1471-2180 urn:isbn:11454238 |
| Idioma(s) |
eng |
| Publicador |
BioMed Central |
| Relação |
http://boris.unibe.ch/25740/ |
| Direitos |
info:eu-repo/semantics/openAccess |
| Fonte |
Cottagnoud, P; Entenza, JM; Cottagnoud, M; Que, YA; Moreillon, P; Taüber, MG (2001). Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae. BMC microbiology, 1(1), p. 9. London: BioMed Central 10.1186/1471-2180-1-9 <http://dx.doi.org/10.1186/1471-2180-1-9> |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
