Synthesis of the bicyclo-[4.3.0]thymidyl nucleoside via Pd(II)-mediated ring expansion chemistry
| Data(s) |
2007
|
|---|---|
| Resumo |
A variety of modified nucleosides to improve antisense oligodeoxynucleotide properties such as target affinity, nuclease resistance, and pharmacokinetics were developed in the last two decades. In the context of conformational restriction we present here the synthesis of the [4.3.0]-bicyclo-DNA thymine monomer via Pd(II)-mediated ring expansion of an intermediate of the tricyclo-DNA synthesis. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/22452/1/NucNucNuc.pdf Stauffiger, Andrea; Leumann, Christian J. (2007). Synthesis of the bicyclo-[4.3.0]thymidyl nucleoside via Pd(II)-mediated ring expansion chemistry. Nucleosides, nucleotides & nucleic acids, 26(6-7), pp. 615-619. Philadelphia, Pa.: Taylor & Francis 10.1080/15257770701490407 <http://dx.doi.org/10.1080/15257770701490407> doi:10.7892/boris.22452 info:doi:10.1080/15257770701490407 urn:issn:1525-7770 |
| Idioma(s) |
eng |
| Publicador |
Taylor & Francis |
| Relação |
http://boris.unibe.ch/22452/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Stauffiger, Andrea; Leumann, Christian J. (2007). Synthesis of the bicyclo-[4.3.0]thymidyl nucleoside via Pd(II)-mediated ring expansion chemistry. Nucleosides, nucleotides & nucleic acids, 26(6-7), pp. 615-619. Philadelphia, Pa.: Taylor & Francis 10.1080/15257770701490407 <http://dx.doi.org/10.1080/15257770701490407> |
| Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
